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Review Article
Vikas A Saharan1,
Vipin
Kukkar1,
Mahesh Kataria1, Manoj Gera1, Pratim K Choudhury2
1 Institute of Pharmaceutical Sciences and Drug Research,
Seth GL Bihani SD College of Technical Education, Sri
Ganganagar, Rajasthan, India
2 Department of Pharmaceutical Sciences, ML Sukhadia
University, Udaipur, Rajasthan, India
For Correspondence:
Vikas
A Saharan, Assistant Professor and In charge, Committee
for Higher Education Guidance (GATE Cell), Seth G. L.
Bihani S. D. College of Technical Education, Gaganpath,
Sri Ganganagar, Rajasthan, India. Mobile:
+91-9799299706 Tel: +91-154-2466777
Fax:
+91-154-2466774
Email:
vikas.pharmaceutics@gmail.com
Received:
03-Dec-08 Revised:
12-Apr-09 Accepted: 05-May-09
International Journal of Health Research,
September
2009; 2(2):
207-223
Abstract
Recent high throughput screening and combinatorial and
parallel synthesis are increasing the number of drug
molecules which are highly lipophilic. The oral route is
the most preferred route of drug administration due to
its convenience, good patient compliance and low
medicine production costs. The challenges to formulation
scientists have tremendously increased due to the
pressure of formulating these lipophilic drugs into oral
drug delivery systems. Reports in patent and scientific
literature are also increasing day by day which shows
the interest of industrial and academic research in
dissolution enhancement of poorly water soluble drugs.
Part I [Int J Health Res, Jun 2009; 2(2):107-124] of
this review was a technological overview on various
dissolution enhancement techniques for poorly water
soluble drugs and role of few water soluble carriers,
viz. polymers, superdisintegrants and surfactants, in
dissolution enhancement. This part describes the use of
cyclodextrin, carbohydrates, hydrotropes, polyglocolized
glycerides, dendrimers, acids and miscellaneous carriers
in enhancing dissolution of drugs.
Keywords:
Dissolution enhancement; aqueous solubility, water
soluble carriers; lipophilic, excipients. |
