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Vikas A Saharan1,
Vipin
Kukkar1,
Mahesh Kataria1, Manoj Gera1, Pratim K Choudhury2
1Institute of Pharmaceutical Sciences and Drug Research,
Seth GL Bihani SD College of Technical Education, Sri
Ganganagar, Rajasthan, India
2Department of Pharmaceutical Sciences, ML Sukhadia
University, Udaipur, Rajasthan, India
For Correspondence:
Vikas
A Saharan, Assistant Professor and In charge, Committee
for Higher Education Guidance (GATE Cell), Seth G. L.
Bihani S. D. College of Technical Education, Gaganpath,
Sri Ganganagar, Rajasthan, India. Mobile:
+91-9799299706 Tel: +91-154-2466777
Fax:
+91-154-2466774
Email:
vikas.pharmaceutics@gmail.com
Received:
03-Dec-08 Revised:
12-Apr-09 Accepted: 05-May-09
International Journal of Health Research,
June
2009; 2(2):
107-124 (e222p3-20)
Review Article
Abstract
For
complete absorption and good bioavailability of orally
administered drug, the drug must be dissolved in gastric
fluids. Dissolution of drug is the rate-controlling step
which determines the rate and degree of absorption.
Drugs with slow dissolution rates generally show erratic
and incomplete absorption leading to low bioavailability
when administered orally. Since aqueous solubility and
slow dissolution rate of BCS class II and class IV drugs
is a major challenge in the drug development and
delivery processes, improving aqueous solubility and
slow dissolution of BCS Class II and Class IV drugs have
been investigated extensively. Various techniques have
been used in attempt to improve solubility and
dissolution rates of poorly water soluble drugs which
include solid dispersion, micronization, lipid based
formulations, melt granulation, direct compaction,
solvent evaporation, coprecipitation, adsorption,
ordered mixing, liquisolid compacts, solvent deposition
inclusion complexation and steam aided granulation. In
these techniques carrier plays an important role in
improving solubility and dissolution rate. Polymers,
superdisintegrants, surfactants are extensively studied
in recent years for dissolution enhancement in drugs.
This part of this review discusses technological
overview and effect of polymers, superdisintegrants and
surfactants on dissolution enhancement of drugs while
Part II [Int J Health Res, Sept 2009; 2(3)] describes
the role and applications of cyclodextrins,
carbohydrates, hydrotropes, polyglocolized glycerides,
dendrimers, acids and miscellaneous carriers in
enhancing dissolution of drugs.
Keywords:
Dissolution enhancement; aqueous solubility, water
soluble carriers; BCS class II, excipients.
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