Effect of Curing Time on pH and Time Dependant Coated
Pellets
Vinayak D Kadam*,
Surendra G Gattani
Department of Pharmaceutics, R.C. Patel Institute of
Pharmaceutical Education and Research, Shirpur, District
Dhule, India 425 405.
*For
Correspondence:
Tel:
+91-9422231100
E-mail:
vinayakkdm@yahoo.com or
Vinayakkadam5@gmail.com
Received:
29-Dec-08 Revised:
10-Jan-09 Accepted: 11-Jan-09
International Journal of Health Research,
March
2009; 2(1):
75-81 (e213p11-17)
Original
Research Article
Abstract
PURPOSE:
The drug release from coated pellets depends on many
process and formulation variables, including
plasticization, curing treatment, and properties of the
core. In this study, effect of currying on eudragit
coated pellets was investigated.
METHODS:
Theophylline loaded pellets were coated with a non
aqueous time and pH dependant eudragit solution.
The coated pellets were cured at constant process parameters (45 °C) for
different time periods (05, 10, or 20 min) and the drug
release profile and other characteristics of formulation
were evaluated.
RESULTS:
In vitro release studies shows retardation of
drug release from the coated pellets. The DSC thermogram
revealed no interaction between the polymer and drug in
the formulation. The SEM data shows no change in the
surface topography after 20 min curing.
CONCLUSION:
In general, curing reduced the drug release and resulted
in stable drug release profiles.
Keywords:
Time and pH
dependant polymers, curing of pellets.
