Gastro-Protective Effects of the Leaf Extract and
Fractions of Fleurya aestuans L (Urticaceae)
CA, Nworu CS* and Ndu OO
Department of Pharmacology and Toxicology, Faculty of
Pharmaceutical Sciences, University of Nigeria, Nsukka,
410001, Enugu State, Nigeria.
05-Oct-08 Revised: 30-Dec-08
International Journal of Health Research,
Original Research Article
To investigate the gastroprotective properties of the
methanol leaf extract and fractions of Fleurya
aestuans L (Urticaceae) in rodents.
Anti-ulcer effect was evaluated in three ulcer models
induced by ethanol, indomethacin and hypothermic-
restraint stress in rats. Other anti-ulcer related
activities of the extract such as the effects on
gastrointestinal motility, and the activity on
contractions evoked by standard agonists on isolated
guinea pig ileum were also determined.
Increasing concentrations of the extracts and fractions
did not produce spasmogenic effect on the isolated
guinea pig ileum, but produced a dose-related inhibition
of contractile responses to histamine and acetylcholine
with IC50 range of 0.245-0.525 and
0.525-1.525 mg/ml, respectively. In the ethanol-induced
ulcer models, administration of the extracts of F.
aestuans at 400 mg/kg reduced the ulcer indices of
all the treated groups, but significant (p <
0.05) ulcer protection was shown by the n-hexane and the
methanol fractions. The rats were also significantly
protected from the indomethacin-induced ulceration by
the methanol extract (p < 0.05). The methanol
extract and the n-hexane fraction conferred significant
(p < 0.05) gastro-protection against ulcers
induced by cold restraint (stress) in rats.
Administration of the ethylacetate fraction (EF, 400
mg/kg) and the n-hexane fraction (HF, 400 mg/kg)
produced significant (p < 0.05) anti-peristaltic
activity reducing gastrointestinal motility in mice in a
The leaf extracts of F. aestuans possess
gatroprotective properties could justify folklore uses
of the plant in peptic ulcer diseases.
Anti-ulcer activity, Fleurya aestuans,
gastro-protection, peptic ulcers