Preliminary Studies on Diuretic Effect of Hygrophila
auriculata (Schum) Heine in Rats
Md
Sarfaraj Hussain*1,
KFH
Nazeer Ahmed1, and
Md Zaheen Hasan Ansari2
*1Department
of
Pharmacognosy
and
Phytochemistry,
Vel’s College of Pharmacy,
Pallavaram, Chennai- 600 117,
India.
2Department of Pharmaceutical
chemistry, Jamia Hamdard, New Delhi 110062.
*For
Correspondence:
Tel: +91-9889902496
E-mail:
sarfarajpharma@gmail.com or
sarfaraj_pharma@yahoomail.com
Received:
25-Aug-08 Revised: 02-Jan-09
Accepted: 02-Jan-09
International Journal of Health Research,
March
2009; 2(1):
59-64 (e216p57-62)
Original Research Article
Abstract
Purpose:
Hygrophila auriculata
is a traditional folk medicine widely used in the
treatment of urinary infection, gout, hepatic
obstruction and as a diuretic. This study was conducted
to examine the diuretic effect of whole plant extracts
and its fractions.
Methods:
The
diuretic effect was examined by treating different
groups of wistar albino rats with single (200
mg/kg) oral doses of alcoholic extract/fractions.
Frusemide (10 mg/kg) was used as positive control in the
study.
The
urine volume and electrolyte concentration (Na+,
K+ and Cl-) were measured.
Results: Out of the
different fractions and extract, the n-butanol fraction
(200 mg/kg) significantly and markedly increased the
urine output (p < 0.01). The pattern of diuresis
induced by the n-butanol fraction was almost similar to
that produced by the frusemide.
Conclusion:
Hygrophila auriculata plant extract posesses
diuretic effects in rats.
Keywords:
Hygrophila
auriculata,
Diuretics, Electrolytes, Terpenoid.
