Antibacterial, antidiarrhoeal and ulcer-protective
activity of methanolic extract of Spondias mangifera
bark
Muhammad Arif*1,
Kamruz Zaman2, Sheeba Fareed1,
Badruddeen3, Md Sarfaraj Hussain1
1Faculty
of Pharmacy, Integral University, Lucknow-26, Uttar
Pradesh
2Department
of Pharmaceutical Sciences, Dibrugarh University,
Dibrugarh-786004, Assam.
3Faculty
of Pharmacy, Jamia Hamdard (Hamdard University), New
Delhi-62 India.
*For
Correspondence:
Tel:
+91-9918464963
E-mail:
arif_sweet@rediffmail.com or
sarfarajpharma@gmail.com
International Journal of Health Research,
March
2009; 2(1):
105-110 (e212p3-8)
Original
Research Article
Retraction Notice
Retracted:
Arif M, Zaman K, Fareed S, Badrudden, Hussain MS.
Antibacterial, antidiarrhoeal and ulcer-protective
activity of methanolic extract of Spondias mangifera bark.
Int J Health Res 2008;1(4):172-182 (e142p11-6).
This article published
online on January 19, 2009 has been retracted and
is being replaced by agreement between the authors, the
journal editor and Poracom Academic Publishers. The
earlier published article was retracted due to wrong
information relating to ethical issues which has been
corrected in this replacement article.
Abstract
PURPOSE:
To evaluate Spondias mangifera bark for
indomethacin-induced ulcer protective and castor-oil
induced antidiarrhoeal activity.
METHODS:
The extracts of S. mangifera were tested for castor-oil
induced diarrhea, and intestinal fluid accumulation and
propulsion in rats using diphenoxylate hydrochloride and
atropine as standard drug. The effect of the extracts on
indomethacin-induced ulceration in rats was also
evaluated. using cimetidine as positive control.
In-vitro antibacterial activity of methanolic and
aqueous extract was also evaluated against Escherichia
coli, Salmonella typhimurium and Vibrio cholerae
bacteria.
RESULTS: There was a significant (p < 0.01) inhibition activity against castor
oil induced diarrhoea and fluid accumulations in rats
when tested at 100 and 200mg/kg. The extracts also
showed significant (p < 0.01) reduction in intestinal
propulsion in charcoal meal test in rats. The methanol
extract inhibited the ulcerogenic effect of indomethacin
and good antibacterial activity.
CONCLUSION:
S. mangifera possesses significant antidiarrhoeal, ulcer protective and
antibacterial activities.
Keywords:
Antidiarrhoeal; Antibacterial; Spondias mangifera bark;
Ulcer protective effect.
