A Study
of
Transdermal Delivery of Glibenclamide Using
Iontophoresis
Ashish Jain1,2*,
Bijaya Ghosh2, Satish Nayak1 and
Vandana Soni3
1Bansal
College of Pharmacy, Kokta, Aanand Nagar, Bhopal, M.P.,
India.
2Department
of Pharmaceutical Techno-logy, K.L.E. Society’s college
of Pharmacy, PMB 1062, II Block, Rajajinagar,
Ban-galore-560010,
India.
3Department
of Pharmaceutical Sciences, Dr H.S.Gour Vishwavidyalaya,
Sagar 470003, M.P. India
*For
Correspondence:
Mobile:
09981574693 Email:
aashish.pharmatech@gmail.com
Received:
16-Jan-09 Revised: 28-Jan-09
Accepted: 29-Jan-09
International Journal of Health Research,
March
2009; 2(1):
83-91 (e2112p101-109)
Original Research Article
Abstract
Purpose:
To assess iontophoretic
transdermal delivery of glibenclamide across pigskin for
its transdermal development.
Methods:
In vitro iontophoretic transdermal delivery of
glibenclamide across the pigskin was investigated at
three different drug concentrations in the donor cell
of the diffusion apparatus, using cathodal iontophoresis
(current density 0.5 mA cm-2) along with the
passive controls.
Results:
For passive
permeation, the steady state flux significantly
increased with the donor drug concentration. At all
concentration levels, iontophoresis considerably
increased the permeation rate compared to passive
controls. Flux enhancement was highest at the lowest
drug load and lowest at the highest drug load.
The highest flux value obtained was 0.0603
mmol
cm-2 h-1 and the target flux for
glibenclamide was 0.3933
mmol
h-1. Required permeation rate was achieved by
iontophoresis using a much smaller application area.
Conclusion:
Permeation rate of drugs across the pigskin can be
considerably enhanced by the use of Iontophoresis.
Keywords:
Glibenclamide; Iontophoresis; Pigskin; Transdermal drug
delivery.
