Study of Interaction Between Antiobesity and
Hypolipidemic Drugs
Nandagopal Anitha1, Jangala V Rao1, Subramaniyam Kavimani2,
Srujitpal Reddy1, Eashwar Rao1
1Department
of Pharmacology, Sultan-ul-Uloom college of Pharmacy,
Road No. 3, Banjara Hills, Hyderabad.
2Mother
Theresa institute of health sciences, Gorimedu,
Pondicherry.
*For
Correspondence:
Tel:
09849387809
E-mail:
jvr1963@yahoo.co.in
International Journal of Health Research,
December
2008; 1(4):
189-195 (e144p26-33)
Received:
21-Aug-08 Revised:
19-Dec-08 Accepted: 20-Dec-08
Original
Research Article
Abstract
PURPOSE:
To explore the interaction between antiobesity drug,
topiramate, and hypolipidemic drug, atorvastatin, in
rats.
METHODS:
Obesity was induced in Wistar albino rats by administering
cafeteria diet (CD) for 40 days and divided into 5
groups. While one group served as control, each other
group received either alone or in combination with
either topiramate, atorvastatin or topiramate plus
atorvastatin. The animals were treated with the drugs
for 7 days. On 7th day, 2 hr after drug
administration, the body weight, organ weights, rectal
temperature, locomotor activity and various biochemical
parameters like serum glucose, total cholesterol (TC),
triglycerides (TG), low-density lipoprotein (LDL) and
high-density lipoprotein (HDL) levels were determined.
The data were analysed statistically.
RESULTS:
There was a significant reduction in body weight, organ
weights, serum glucose, serum TC, TG, LDL and increase
in body temperature, locomotor activity and HDL levels
in cafeteria diet fed rats treated with the combination
of topiramate and atorvastatin when compared with those
treated with topiramate and atorvastatin alone.
CONCLUSION:
There is
interaction between topiramate and atorvastatin when
administered together.
Keywords:
Antiobesity drugs; Atorvastatin; Drug interaction;
Hypolipidemic; Topiramate.
