Antibacterial, antidiarrhoeal and ulcer-protective
activity of methanolic extract of Spondias mangifera
bark
Muhammad Arif*1,
Kamruz Zaman2, Sheeba Fareed1,
Badruddeen3, Md Sarfaraj Hussain1
1Faculty
of Pharmacy, Integral University, Lucknow-26, Uttar
Pradesh
2Department
of Pharmaceutical Sciences, Dibrugarh University,
Dibrugarh-786004, Assam.
3Faculty
of Pharmacy, Jamia Hamdard (Hamdard University), New
Delhi-62 India.
*For
Correspondence:
Tel:
+91-9918464963
E-mail:
arif_sweet@rediffmail.com or
sarfarajpharma@gmail.com
International Journal of Health Research,
December
2008; 1(4):
177-182 (e142p11-16)
Received:
01-Sep-08 Revised: 19-Dec-08
Accepted: 24-Dec-08
Original
Research Article
Abstract
PURPOSE:
To evaluate Spondias mangifera bark for
indomethacin-induced ulcer protective and castor-oil
induced antidiarrhoeal activity.
METHODS:
The extracts of S. mangifera were tested for castor-oil
induced diarrhea, and intestinal fluid accumulation and
propulsion in rats using diphenoxylate hydrochloride and
atropine as standard drug. The effect of the extracts on
indomethacin-induced ulceration in rats was also
evaluated. using cimetidine as positive control.
In-vitro antibacterial activity of methanolic and
aqueous extract was also evaluated against Escherichia
coli, Salmonella typhimurium and Vibrio cholerae
bacteria.
RESULTS: There was a significant (p < 0.01) inhibition activity against castor
oil induced diarrhoea and fluid accumulations in rats
when tested at 100 and 200mg/kg. The extracts also
showed significant (p < 0.01) reduction in intestinal
propulsion in charcoal meal test in rats. The methanol
extract inhibited the ulcerogenic effect of indomethacin
and good antibacterial activity.
CONCLUSION:
S. mangifera possesses significant antidiarrhoeal, ulcer protective and
antibacterial activities.
Keywords:
Antidiarrhoeal; Antibacterial; Spondias mangifera bark;
Ulcer protective effect.
