Evaluation of Hepatoprotective Activity of the Fruits of
Coccinia grandis Linn
Vadivu R1, Krithika A2, Biplab C
Dedeepya2, Shoeb N2, Lakshmi KS2
1Department
of Pharmacognosy, Madras Medical College, Chennai-600
003, India
2SRM
College of Pharmacy, Kattankulathur, Chennai, India
E-mail:
*For
Correspondence:
Email:
r.vadivu@rediffmail.com
International Journal of Health Research,
September
2008; 1(3):
163-168
Received: 02-Jul-08 Revision
received: 31-Aug-08 Accepted for publication:
19-Sep-08
Original
Research Article
Abstract
Purpose:
To evaluate the hepatoprotective activity of alcoholic
extract of the fruits of Coccinia grandis Linn (Curcubitaceae)
using carbon tetra chloride (CCl4)-induced
hepatotoxicity in rats.
Methods:
The levels of serum glutamate oxaloacetate transminase (SGOT),
serum glutamate pyruate transminase (SGPT), alkaline
phosphatase (ALP), total protein, total and direct
bilirubin were evaluated in experimental rats (with or
without CCl4-induced hepatotoxicity)
following administration of alcoholic extract of the
fruits of C. grandis using standard procedures. The
potency of the extract was compared with standard
silymarin at a dose of 100 mg/kg p.o. Histopathology of
the liver tissues of the animals treated with the
extract was also studied.
Results:
At a dose level of 250 mg/kg, the alcoholic extract
significant (p<0.05) decreased the activities of serum
enzymes (SGOT, SGPT, and ALP) and bilirubin which were
comparable to that of silymarin.
Conclusion:
Alcoholic
extract of the fruits of C. grandis offers protective
effect against CCl4-induced hepato-toxicity
in experimental rats.
Keywords:
CCl4-induced
hepatotoxicity; Coccinia grandis; hepatoprotective
effect; silymarin
