Antitumour Activity of Methanolic Extract of Plumeria
alba L. Leaves Against Dalton Lymphoma Ascites in
Mice
Ramalingam Radha1*, Subramaniyam Kavimani2,
Velayudham Ravichandran3
1Department
of Pharmaceutical Sciences, Madras Medical College,
Chennai-3
2Mother
Therasa Institute of Health Sciences, Gorimedu,
Puducherry.
3Vels
College of Pharmacy, Pallavaram, Chennai.
*For Correspondence:
Department of Pharmacognosy,
Madras Medical College, Chennai-60000,Tamil Nadu, India.
E-mail:
rradha1970@yahoo.co.in
Tel:
9884641156.
International Journal of Health Research,
June
2008; 1(2):
79-85
Received: 12-Jun-08 Revision received:
20-Jun-08 Accepted for publication: 21-Jun-08
Original Research Article
Abstract
Purpose:
To evaluate Plumeria alba leaves for antitumor activity
against Ehrlich ascites carcinoma (EAC) and Dalton
lymphoma ascites (DLA) bearing Swiss albino mice.
Method:
The antitumour activity of the methanolic extract of
Plumeria alba leaves (MPA) was evaluated against EAC and
DLA using in-vitro cytotoxic and mean survival time, a
decrease in the tumour volume and viable cell count in
the DLA tumour hosts. The animal was observed for
improvement in the haematological parameters (e.g.,
heamoglobin content, red and white blood cells count,
and differential cell count) following MPA treatment of
the tumour bearing mice.
Results:
MPA was found to be cytotoxic in the in-vitro model.
Intraperitoneal administration of MPA increased the
survival time, dead cell count haematological parameters
and solid tumour mass was also significantly reduced.
Conclusion:
MPA possesses significant antitumour
activity.
Keywords:
Antitumour, cytotoxicit,y Plumeria alba L
